Breadcrumb Animal Models of Cancer Conference Tuesday, 18 July 2023 - 02:00 - Friday, 21 July 2023 - 02:00 Animal Models of Cancer Conference This conference will focus on three major areas: First, it will present new approaches to generate precise and complex genetic alterations in mice and other animals to better “humanize” models and allow for in vivo studies of cancer gene function. The first genetically engineered mice were created more than 40 years ago. Since then, steady improvements in the field have allowed for the generation of experimentally controllable and genetically accurate models for many human cancers. Recent technological advances in genome editing are pushing this frontier and new animal models are directly impacting precision medicine approaches by enabling the functional evaluation of larger numbers of genetic and epigenetic alterations, by providing pre-clinical and co-clinical platforms to evaluate new therapies, and by allowing for the detailed study of tumor biology that cannot be approached in cell-based systems, immunocompromised animals, or patients. While animal modeling has been a staple of the cancer biology community for decades, it is only now maturing to its fullest potential. This conference will focus on three major areas: First, it will present new approaches to generate precise and complex genetic alterations in mice and other animals to better “humanize” models and allow for in vivo studies of cancer gene function. Second, it will highlight studies to investigate fundamental mechanisms of cancer initiation and progression, including the cell of origin of tumors, their evolution, their metabolism, and their interactions with the immune system. Finally, the meeting will explore how genetically engineered animal models can help evaluate the efficacy of novel therapeutic approaches and to decipher mechanisms of therapeutic resistance. Key Sessions New technologies for cancer modelling Modeling pre-cancers and tumor initiation Cancer metabolism Cancer/immune interactions and tumor microenvironment Metastasis Preclinical trials and resistance Chairs Kevin Haigis (Dana-Farber Cancer Institute) Julien Sage (Stanford University) Confirmed Keynote Speakers Ron DePinho (MD Anderson Cancer Center) Tyler Jacks (MIT) Karen Vousden (The Francis Crick Institute) Event Information Organiser Fusion Conferences Date and time Tuesday, 18 July 2023 - 02:00 - Friday, 21 July 2023 - 02:00 Email admin@fusion-conferences.com website https://www.fusion-conferences.com/conference/147 Location Dolce CampoReal Lisboa 2565-770 Lisbon Portugal Last update Thursday 13 July 2023 Share this page