6th DNA Repair/Replication Structures and Cancer Conference

Synopsis

The 6th DNA Repair/Replication Structures & Cancer conference on 14-18 February 2024 will focus on molecular structural and mechanistic insights into dynamic complexes acting in DNA repair, replication, and inflammation and their intersections relevant to advanced cancer therapies. This fundamental information will be pivotal for pioneering research on DNA damage responses as well as for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions, collaborations, and insights. In this conference and this area of science basic research is empowering medical advances and clinical data are unveiling basic relationships in ways that are completely changing how research and translation is being done.

Key Sessions

Sessions will include emerging results and breakthrough methodologies on core topics including:

• Double-Strand Break Repair by homologous recombination, non-homologous end joining, and alternative end joining. 
• Base and Nucleotide Excision Repair and Mismatch Repair 
• Replication stress and replication-associated repair 
• Repair in Mitosis and Meiosis
• DNA and protein-DNA crosslinking repairs
• DDR and inflammation in disease and therapeutics 
• DNA damage response at telomeres 
• Molecular machines in DNA repair regulation
• DDR signalling and pathway choices
• Repair in the chromosome context 
• New repair mechanisms and methodologies  
• Transcription-repair interfaces 

Plenary Speakers

Maria Jasin (Memorial Sloan Kettering)

Titia de Lange (Rockefeller University)

Rising Star Plenary Speaker

Irene Chiolo (University of Southern California)

Confirmed Speakers

Ranjit S. Bindra (Yale School of Medicine)

Simon Boulton (Francis Crick Institute)

Cynthia Burrows (University of Utah)

Junjie Chen (MD Anderson Cancer Center)

Karlene Cimprich (Stanford University)

Francesca Cole (MD Anderson Cancer Center)

Sylvie Doublié (University of Vermont)

Samir Hamdan (KAUST)

Yuan He (Northwestern University)

Karl Peter Hopfner (Ludwig Maximilian University of Munich)

Ben Van Houten (University of Pittsburgh)

Stephen Kowalczykowski (University of California, Davis)

Susan Lees-Miller (University of Calgary)

John Pascal (University of Montreal)

Lori Passmore (MRC Laboratory of Molecular Biology)

Helen Robinson (Artios)

Eli Rothenberg (New York University)

Katharina Schlacher (MD Anderson Cancer Center)

Jessica Tyler (Weill Cornell Medicine)

Johannes Walter (Harvard Medical School)

Dale Wigley (Imperial College London)

Scott Williams (NIH)

Timothy Yap (MD Anderson Cancer Center)

Steve West (Francis Crick Institute)

Wei Yang (NIH)

Xiaolan Zhao (Memorial Sloan Kettering Cancer Center)

Michael Zinda (Repare Therapeutics)